坏死性凋亡在糖尿病性创面愈合中的研究进展
DOI:
https://doi.org/10.70693/cjmsr.v1i1.688Keywords:
糖尿病性创面；坏死性凋亡；相关蛋白；研究进展Abstract
糖尿病作为临床常见的慢性代谢性疾病，其显著特征为长期的高血糖状态，这一病理条件可引发生化反应的连锁变化，进而累及全身多个系统和器官。在众多并发症中，糖尿病所导致的创面问题以其高发性和难治性而备受关注，糖尿病创面通常表现为皮肤溃疡、感染反复发作以及组织坏死等临床特征。若得不到及时有效的治疗，严重者可致残，甚至引发脓毒血症等危及生命的并发症。因而，探寻有效方法以提升糖尿病性创面的治愈率，已成为亟待攻克的医学难题。坏死性凋亡作为一种新兴发现的细胞程序性死亡途径，能够参与并调控多种炎症反应过程。近年来的研究成果显示，坏死性凋亡在糖尿病的发病进程中扮演了关键角色，尤其在糖尿病性创面愈合方面，发挥着至关重要的作用。本文通过探讨坏死性凋亡与创面相关蛋白的研究及其在糖尿病性创面愈合中的作用机制，旨在为相关领域的研究人员提供参考和启示，为糖尿病性创面愈合治疗的进一步发展提供借鉴。
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