心血管疾病中内皮细胞调控机制的研究进展
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https://doi.org/10.70693/cjmsr.v1i1.554关键词:
心血管疾病, 内皮细胞, 功能失调, 分子机制, 治疗靶点摘要
心血管疾病是全球范围内导致死亡和致残的主要原因之一,其中血管内皮细胞功能障碍在疾病发生与进展中发挥了至关重要的作用。血管内皮细胞通过分泌一氧化氮(NO)和内皮素(ET)等活性分子调控血管张力,参与炎症反应与血管新生等过程。近年来,随着分子生物学与组学技术的飞速发展,内皮细胞调控机制在氧化应激、代谢异常、炎症反应、细胞凋亡与自噬等层面的研究不断深入。本综述系统概述了内皮细胞的结构功能、功能失调的分子机制及其在动脉粥样硬化、高血压、心力衰竭等心血管疾病中的关键作用,探讨了相关的治疗靶点和干预策略,最后对当前研究挑战及未来展望进行了总结。深入理解内皮细胞调控机制将为心血管疾病的新型治疗策略提供重要思路。
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