短链脂肪酸与眼部疾病的研究进展
##plugins.pubIds.doi.readerDisplayName##:
https://doi.org/10.70693/cjmsr.v1i1.693关键词:
短链脂肪酸；糖尿病性视网膜病变；葡萄膜炎；角膜炎；摘要
摘要：链簇（短链脂肪酸，SCFAs）是损伤群短发酵产物，在维持悬架作用、调节免疫反应及抑制调节反应中发挥重要作用。近年来，研究发现SCFAs可能通过肠眼轴影响部分疾病的发生与发展。文章综述了SCFAs在眼部疾病中的作用机制，重点关注其在糖尿病性损伤、葡萄膜炎和炎症中的研究进展，探讨其作为潜在治疗靶点的可能性。
项目基金：重庆医科大学附属大学城医院“高层次人才引进计划”科研启动基金
参考
Rooks, Michelle G., Garrett, et al. Gut microbiota, metabolites and host immunity[J]. Nature reviews. Immunology, 2016, 16(6):341-52.
Du Y, He C, An Y, et al. The Role of Short Chain Fatty Acids in Inflammation and Body Health[J]. Int J Mol Sci. 2024 Jul 5;25(13):7379.
Insull W Jr. Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: a scientific review[J]. South Med J. 2006 Mar;99(3):257-73.
den Besten G, van Eunen K, Groen AK, et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism[J]. J Lipid Res. 2013 Sep;54(9):2325-40.
Gill PA, van Zelm MC, Muir JG, et al. Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders[J]. Aliment Pharmacol Ther. 2018 Jul;48(1):15-34.
Grant MB, Bernstein PS, Boesze-Battaglia K, et al. Inside out: Relations between the microbiome, nutrition, and eye health[J]. Exp Eye Res. 2022 Nov;224:109216.
Yan M, Li X, Sun C, et al. Sodium Butyrate Attenuates AGEs-Induced Oxidative Stress and Inflammation by Inhibiting Autophagy and Affecting Cellular Metabolism in THP-1 Cells[J]. Molecules. 2022 Dec 9;27(24):8715.
Wu J, Chen N, Grau E, et al. Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43[J]. Ocul Surf. 2024 Apr;32:48-57.
Chen N, Wu J, Wang J, et al. Short chain fatty acids inhibit endotoxin-induced uveitis and inflammatory responses of retinal astrocytes[J]. Exp Eye Res. 2021 May;206:108520.
Singh S, Singh PK, Kumar A. Butyrate Ameliorates Intraocular Bacterial Infection by Promoting Autophagy and Attenuating the Inflammatory Response[J]. Infect Immun. 2023 Jan 24;91(1):e0025222.
Huang Y, Wang Z, Ye B, et al. Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids[J]. J Transl Med. 2023 Jul 7;21(1):451.
Nguyen Y, Rudd Zhong Manis J, Ronczkowski NM, et al. Unveiling the gut-eye axis: how microbial metabolites influence ocular health and disease[J]. Front Med (Lausanne). 2024 May 10;11:1377186.
Prasad R, Asare-Bediko B, Harbour A, et al. Microbial signatures in the rodent eyes with retinal dysfunction and diabetic retinopathy[J]. Investig Ophthalmol Vis Sci. 2022;63:5.
Beli E, Yan Y, Moldovan L, et al. Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice[J]. Diabetes. 2018;67:1867–1879.
Trotta MC, Gesualdo C, Herman H, et al. Systemic Beta-Hydroxybutyrate Affects BDNF and Autophagy into the Retina of Diabetic Mice[J]. Int J Mol Sci. 2022 Sep 5;23(17):10184.
Schaefer L, Hernandez H, Coats RA, et al. Author Correction: Gut-derived butyrate suppresses ocular surface inflammation[J]. Sci Rep. 2022 Apr 21;12(1):6581.
Nakamura YK, Janowitz C, Metea C, et al. Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine[J]. Sci Rep. 2017 Sep 18;7(1):11745.
Krix-Jachym K , Onyszkiewicz M , Witkiewicz M ,et al.Evaluation of butyric acid as a potential supportive treatment in anterior uveitis[J].Ophthalmology Journal, 2022.
Xiao X , Chen M , Xu Y ,et al. Sodium Butyrate Inhibits Neovascularization Partially via TNXIP/VEGFR2 Pathway[J].Oxidative Medicine and, Cellular Longevity, 2020, 2020:1-13.
Reis JSD, Dos Reis Teixeira A, De Vasconcelos Quaresma A, et al. Sodium butyrate-loaded nanoparticles coated with chitosan for the treatment of neovascularization in age-related macular degeneration: Ocular biocompatibility and antiangiogenic activity[J]. Eur J Pharm Biopharm. 2022 Oct;179:26-36.
Baldi S, Pagliai G, Di Gloria L, et al. Beneficial Effects of Micronutrient Supplementation in Restoring the Altered Microbiota and Gut-Retina Axis in Patients with Neovascular Age-Related Macular Degeneration-A Randomized Clinical Trial[J]. Nutrients. 2024 Nov 20;16(22):3971.
Chang C C J , Liu B , Liebmann J M ,et al. Glaucoma and the Human Microbiome[J].Journal of glaucoma, 2025-02-26. 33(8):529-538
Vergroesen JE, Jarrar ZA, Weiss S, et al. Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut[J]. Invest Ophthalmol Vis Sci. 2024 Feb 1;65(2):7.
##submission.downloads##
已出版
##submission.howToCite##
期
栏目
##submission.license##
##submission.copyrightStatement##
##submission.license.cc.by4.footer##